Antonio Bedalov
All males have one X and one Y chromosome; females have two X chromosomes.To maintain the proper dosage of genetic information, females randomly inactivate one X in every cell. Since the MECP2 gene resides on the X chromosome, females with Rett have one healthy and one mutated gene in every cell. This means that in every cell with a damaged MECP2 gene there is a healthy copy lying dormant.
In this project, based in the laboratory of Antonio Bedalov, M.D., Ph.D. at the Fred Hutchinson Cancer Research Center in Seattle, Washington, scientists are attempting to identify drugs/compounds or genes that will activate the silent copy of MECP2.
RSRT UK funding delivered to this project in 2010: £14,800
RSRT UK funding delivered to this project in March 2011: £6250
RSRT UK funding delivered to this project in June 2011: £9775
Tota RSRT UK funding delivered to this project to date: £30,825