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Modifier genes

Another avenue to treating Rett Syndrome is to find ways to bypass the need for MeCP2.

One way that this can be done is by identifying other genes which, when mutated, somehow protect an individual from a MECP2 mutation.

There are also people who have common MECP2 mutations and normal X chromosome inactivation who do not have Rett Syndrome. Identifying which genes protect some people from developing Rett Syndrome – known as ‘modifier genes’ – could open up new avenues for treatment.

Reverse Rett is providing ongoing financial support for projects aiming to identify modifier genes.

You can read more about this work on the RSRT website here Just scroll down to Current Projects and click on the Modifier Genes tab.