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MECP2 Duplication Syndrome

MECP2 Duplication Syndrome is caused by problems with the same gene as Rett Syndrome.

But whilst Rett is caused by mistakes or mutations in the gene, this syndrome is caused by a duplication of the gene.

It is mostly boys who are affected by MECP2 Duplication Syndrome. The symptoms are similar to those we see in Rett; developmental delay with no or very little speech, floppiness, difficulties with feeding, seizures, mobility issues and compromised immune functioning.

The MECP2 Duplication Fund at Reverse Rett

In 2012, a parent-driven effort was established to raise funds for the initial MECP2 Duplication reversal experiments conducted at the Baylor College of Medicine. Several families pledged to raise $401each to cover the cost of the experiments. The initiative was a success, and the 401 Project was born. All funds raised through the 401 Project initiative are directly deposited into the MECP2 Duplication Syndrome Fund at RSRT.

Reverse Rett supports the efforts of UK families working as part of the 401 Project by holding a designated fund for MECP2 Duplication Syndrome research.

100% of funds which are raised for the MECP2 Duplication Fund at Reverse Rett are delivered to MECP2 research focused projects every quarter via RSRT.

If you wish to support the MECP2 Duplication Fund at Reverse Rett, here is what you can do:

Donate here or

set up a fundraising page here.

PLEASE NOTE, IT IS ESPECIALLY IMPORTANT THAT IF YOU WISH TO FUNDRAISE FOR OR DONATE TO THE MECP2 DUPLICATION FUND, YOU SET UP YOUR FUNDRAISING PAGE OR MAKE YOUR DONATION VIA THE ABOVE LINKS TO THE MECP2 DUPLICATION CAMPAIGN. IF YOU NEED ANY HELP, PLEASE DO NOT HESITATE TO CONTACT US ON 0161 434 8117 OR BY EMAIL ENQUIRIES@REVERSERETT.ORG.UK

THANK YOU